Engman Lab Publications

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Emmer, B.T., Souther, C., Toriello, K.M., Olson, C.L., Epting, C.L. and Engman, D.M. (2009) Identification of a palmitoyl acyltransferase required for protein sorting to the flagellar membrane. J. Cell Sci. 122, 867-874. PMID: 19240115. [PubMed] [PDF]

Tyler, K.M., Fridberg, A., Toriello, K.M., Olson, C.L., Cieslak, J.A., Hazlett, T.L. and Engman, D.M. (2009) Flagellar membrane localization via association with lipid rafts. J. Cell Sci. 122, 859-866. PMID: 19240119. [PubMed] [PDF]

Kulkarni M.M., Olson C.L., Engman D.M. and McGwire, B.S. (2009) Trypanosoma cruzi gp63s undergo stage-specific differential posttranslational modification and are important for host cell infection. Infection and Immuninty 77 :2193-2200. PMID: 19273559. [PubMed] [PDF]

Bonney K.M., Engman D.M. (2008) Chagas heart disease pathogenesis: one mechanism or many. Current Molecular Medicine 8: 510-518. PMID: 18781958. [PubMed]

Daniels M.D., Hyland K.V., Wang K., Engman D.M. (2008) Recombinant cardiac myosion fragment induces experimental autoimmune myocarditis via activation of Th1 and Th17 immunity. Autoimmunit, 41 (6): 490-499. PMID: 18781477. [PubMed] [PDF]

Wingard J.N., Ladner J., Vanarotti M., Fisher A., Robinson H., Buchanan K.T., Engman D.M., Ames J.B. (2008) Structural insights into membrane-targeting by the flagellar calcium-binding protein (FCaBP), a myristoylated and palmitoylated calcium sensor in T. cruzi Journal of Biological Chemistry 283(34): 23388-96. PMID: 18559337. [PubMed] [PDF]

Hyland K.V., Asfaw, S.H., Olson C.L., Daniels M.D., Engman D.M. (2008) Bioluminescent imaging of Trypanosoma cruzi infection. International Journal of Parasitology 38, 1391-1400. PMID: 18511053. [PubMed] [PDF]

Fridberg A., Olson C.L., Nakayasu E.S., Tyler K.M., Almeida I.C., Engman D.M. (2008) Spingolipid synthesis is necessary for kinetoplast segregation and cytokinesis in Trypanosoma brucei. Journal of Cell Science 121(Pt 4), 522-35. PMID: 18230649. [PubMed] [PDF]

Bahk T.J., Daniels M.D., Leon J.S., Wang K., Engman .DM. (2008) Comparison of angiotensin converting enzyme inhibition and angiotensin II receptor blockade for the prevention of experimental autoimmune myocarditis. International Journal of Cardiology 125(1), 85-93. PMID: 17588693. [PubMed] [PDF]

Hyland K.V., Leon J.S., Daniels M.D., Giafis N., Woods L.M., Bahk T.J., Wang K., Engman D.M. (2007) Modulation of autoimmunity by treatment of an infectious disease. Infection and Immunity 75(7), 3641-50. PMID: 17485457. [PubMed] [PDF]

Kulkarni M.M., McMaster W.R., Kamysz E., Kamysz W., Engman D.M., McGwire B.S. (2006) The major surface-metalloprotease of the parasitic protozoan, Leishmania, protects against antimicrobial peptide-induced apoptotic killing. Molecular Microbiology 62(5), 1484-97. PMID: 17074074. [PubMed] [PDF]

Daniels, M.D., Hyland, K.V., and Engman D.M. (2007) Treatment of Experimental Myocarditis via Modulation of the Renin-Angiotensin System. Current Pharmaceutical Design 13, 1299-1305. PMID: 17506715. [PubMed] [PDF]

Fridberg, A., Buchanan, K.T., and Engman D.M. (2007) Flagellar membrane trafficking in kinetoplastids. Parasitology Research. 100(2), 205-12. PMID: 17058110. [PubMed] [PDF]

Hyland, K.V. and Engman D.M. (2006) Further thoughts on where we stand on the autoimmunity hypothesis of Chagas disease. Trends in Parasitology 22, 101-102. PMID: 16446117. [PubMed] [PDF]

Cunha-Neto, E., Bilate, A.M., Hyland, K.V., Fonseca, S.G., Kalil, J., and Engman D.M. (2006) Induction of cardiac autoimmunity in Chagas heart disease: a case for molecular mimicry. Autoimmunity 39, 41-54. PMID: 16455581. [PubMed] [PDF]

Buchanan, K.T., Ames, J.B., Asfaw, S.H., Wingard, J.N, Olson, C.L., Campana, P.T., Araujo, A.P.U. and Engman, D.M. (2005) A flagellum-specific calcium sensor. Journal of Biological Chemistry 280, 40104-40111. PMID: 16148003. [PubMed] [PDF]

Croxford, J.L., Wang, K., Miller, S.D., Engman D.M. and Tyler, K.M. (2005) Effects of cannabinoid treatment on Chagas disease pathogenesis: balancing inhibition of parasite invasion and immunosuppression. Cellular Microbiology 7, 1592-1602. PMID: 16207246. [PubMed] [PDF]

Tyler, K.M, Luxton, G.W.G., Applewhite, D.A., Murphy, S.C. and Engman, D.M. (2005) Responsive microtubule dynamics promote cell invasion by Trypanosoma cruzi. Cellular Microbiology 7, 1579-1591. PMID: 16207245. [PubMed] [PDF]

Leon, J.S., Daniels, M.D., Toriello, K.M., Wang, K. and Engman, D.M. (2004) A cardiac myosin-specific autoimmune response is induced by immunization with Trypanosoma cruzi proteins. Infection and Immunity 72, 3410-3417. PMID: 15155647. [PubMed] [PDF]

Leon, J.S., Wang, K. and Engman D.M. (2003) Myosin autoimmunity is not essential for cardiac inflammation in acute Chagas disease. Journal of Immunology 171, 4271-4277. PMID: 14530351. [PubMed] [PDF]

McGwire B.S., Olson C.L., Tack B.F., Engman D.M. (2003) Killing of african trypanosomes by antimicrobial peptides. Journal of Infectious Diseases 188, 146-152. PMID: 12825184. [PubMed] [PDF]

Godsel L.M., Leon J.S., Wang K., Fornek J.L., Molteni A., Engman D.M. (2003) Captopril prevents experimental autoimmune myocarditis. Journal of Immunology 171, 346-352. PMID: 12817017. [PubMed] [PDF]

Leon, J.S., Wang, K. and Engman D.M. (2003) Captopril ameliorates myocarditis in acute experimental Chagas disease. Circulation 107, 2264-2269. PMID: 12707246. [PubMed] [PDF]

McGwire, B.S., Chang, K.P. and Engman, D.M. (2003) Migration through the extracellular matrix by the parasitic protozoan Leishmania is enhanced by surface metalloprotease gp63. Infection and Immunity 71, 1008-1010. PMID: 12540585. [PubMed] [PDF]

Leon, J.S., Engman, D.M. (2003) The significance of autoimmunity in the pathogenesis of Chagas heart disease. Frontiers in Bioscience 8, e315-322. PMID: 12700038. "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12700038&dopt=Abstract"target="_Blank">[PubMed] [PDF]

Leon, J.S., Engman, D.M. (2003) The contribution of autoimmunity to Chagas disease? In World Class Parasites: American Trypanosomiasis. Vol 7. (Tyler, K.M., Miles, M.A., eds.). Kluwer Academic Publishers. Boston. [PDF]

Godsel, L.M., Leon, J.S., Engman, D.M. (2003) Angiotensin converting enzyme inhibitors and angiotensin II receptor antagonists in experimental myocarditis. Current Pharmaceutical Design 9, 723-735. PMID: 12570790. [PubMed] [PDF]

McGwire B.S., O'Connell W.A., Chang K.P., Engman D.M. (2002) Extracellular release of the glycosylphosphatidylinositol (GPI)-linked Leishmania surface metalloprotease, gp63, is independent of GPI phospholipolysis: implications for parasite virulence. Journal of Biological Chemistry 277, 8802-8809. PMID: 11777912. [PubMed] [PDF]

Engman D.M., Leon J.S. (2002) Pathogenesis of Chagas heart disease: role of autoimmunity. Acta Tropica 81, 123-132. PMID: 11801219. [PubMed] [PDF]

Leon, J.S., Godsel, L.M., Wang, K. and Engman D.M. (2001) Cardiac myosin autoimmunity in acute Chagas' heart disease. Infection and Immunity 69, 5643-5649. PMID: 11500440. [PubMed] [PDF]

Godsel, L.M., Wang, K., Schodin, B.A., Leon, J.S., Miller, S.D., Engman, D.M. (2001) Prevention of autoimmune myocarditis through the induction of antigen-specific peripheral immune tolerance. Circulation 103, 1709-1714. PMID: 11274001. [PubMed] [PDF]

Tyler, K.M. and Engman D.M. (2001) The life cycle of Trypanosoma cruzi revisited. International Journal for Parasitology 31, 472-480. PMID: 11334932. [PubMed] [PDF]

Leon, J.S. and Engman D.M. (2001) Autoimmunity in Chagas heart disease. International Journal for Parasitology 31, 555-561. PMID: 11334942.[PubMed] [PDF]

Tyler, K.M. and Engman, D.M. (2000) Flagellar elongation induced by glucose limitation is preadaptive for Trypanosoma cruzi. Cell Motility and the Cytoskeleton 46, 269-278. PMID: 10962481. [PubMed] [PDF]

Godsel, L.M. and Engman, D.M. (1999) Flagellar protein localization mediated by a calcium-myristoyl/palmitoyl switch mechanism. EMBO Journal 18, 2057-2065. PMID: 10205160. [PubMed] [PDF]

Maldonado, R.A., Mirzoeva, S., Godsel, L.M., Lukas, T.J., Watterson, D.M., de Oliveira, L., Goldenberg, S. and Engman, D.M. (1999) Identification of calcium binding sequences in the trypanosome flagellar calcium acyl switch protein. Molecular and Biochemical Parasitology 101, 61-70. PMID: 10413043. [PubMed] [PDF]

Carreira, M.A., Tibbetts, R.S., Olson, C.L., Schuster, C., Renz, M., Engman, D.M. and Goldenberg, S. (1998) TcDJ1, a putative mitochondrial DnaJ protein in Trypanosoma cruzi. FEMS Microbiology Letters 166, 141-146. PMID: 9741092. [PubMed]

Tibbetts, R.S., Jensen, J.L., Olson, C.L., Wang, F.D. and Engman, D.M. (1998) The DnaJ family of protein chaperones in Trypanosoma cruzi. Molecular and Biochemical Parasitology 91, 319-326. PMID: 9566524. [PubMed]

Krautz, G.M., Peterson, J.D., Godsel, L.M., Krettli, A.U. and Engman, D.M. (1998) Human antibody responses to Trypanosoma cruzi 70-kD heat-shock proteins. American Journal of Tropical Medicine and Hygiene 58, 137-143. PMID: 9502594. [PubMed]

Maldonado, R.A., Linss, J., Thomaz, N., Olson, C.L., Engman, D.M. and Goldenberg, S. (1997) Homologues of the 24-kDa flagellar Ca(2+)-binding protein gene of Trypanosoma cruzi are present in other members of the Trypanosomatidae family. Experimental Parasitology 86, 200-205. PMID: 9225770. [PubMed]

Godsel, L.M., Olson, C.L., Lacava, Z.G. and Engman, D.M. (1995) Comparison of the 24 kDa flagellar calcium-binding protein cDNA of two strains of Trypanosoma cruzi. Journal of Eukaryotic Microbiology 42, 320-322. PMID: 7496390. [PubMed]

Godsel, L.M., Tibbetts, R.S., Olson, C.L., Chaudoir, B.M. and Engman, D.M. (1995) Utility of recombinant flagellar calcium-binding protein for serodiagnosis of Trypanosoma cruzi infection. Journal of Clinical Microbiology 33, 2082-2085. PMID: 7559952. [PubMed]

Klein, K.G., Olson, C.L., Donelson, J.E. and Engman, D.M. (1995) Molecular comparison of the mitochondrial and cytoplasmic hsp70 of Trypanosoma cruzi, Trypanosoma brucei and Leishmania major. Journal of Eukaryotic Microbiology 42, 473-476. PMID: 7581323. [PubMed]

Klein, K.G., Olson, C.L. and Engman, D.M. (1995) Mitochondrial heat shock protein 70 is distributed throughout the mitochondrion in a dyskinetoplastic mutant of Trypanosoma brucei. Molecular and Biochemical Parasitology 70, 207-209. PMID: 7637705. [PubMed]

Palmer, G., Louvion, J.F., Tibbetts, R.S., Engman, D.M. and Picard, D. (1995) Trypanosoma cruzi heat-shock protein 90 can functionally complement yeast. Molecular and Biochemical Parasitology 70, 199-202. PMID: 7637703. [PubMed]

Sullivan, M.A., Olson, C.L., Winquist, A.G. and Engman, D.M. (1994) Expression and localization of Trypanosoma cruzi hsp60. Molecular and Biochemical Parasitology 68, 197-208. [PubMed] [PDF]

Engman, D.M., Henkle-Duhrsen, K., Kirchhoff, L.V. and Donelson, J.E. (1995) Trypanosoma cruzi: accumulation of polycistronic hsp70 RNAs during severe heat shock. Experimental Parasitology 80, 575-577. PMID: 7729493. [PubMed]

Tibbetts, R.S., Klein, K.G. and Engman, D.M. (1995) A rapid method for protein localization in trypanosomes. Experimental Parasitology 80, 572-574. PMID: 7537220. [PubMed]

Tibbetts, R.S., Kim, I.Y., Olson, C.L., Barthel, L.M., Sullivan, M.A., Winquist, A.G., Miller, S.D. and Engman, D.M. (1994) Molecular cloning and characterization of the 78-kilodalton glucose-regulated protein of Trypanosoma cruzi. Infection and Immunity 62, 2499-2507. [PubMed]

Olson, C.L., Nadeau, K.C., Sullivan, M.A., Winquist, A.G., Donelson, J.E., Walsh, C.T. and Engman, D.M. (1994) Molecular and biochemical comparison of the 70-kDa heat shock proteins of Trypanosoma cruzi. Journal of Biological Chemistry 269, 3868-3874. [PubMed]

Tibbetts, R.S., McCormick, T.S., Rowland, E.C., Miller, S.D. and Engman, D.M. (1994) Cardiac antigen-specific autoantibody production is associated with cardiomyopathy in Trypanosoma cruzi-infected mice. Journal of Immunology 152, 1493-1599. [PubMed]

Effron, P.N., Torri, A.F., Engman, D.M., Donelson, J.E. and Englund, P.T. (1993) A mitochondrial heat shock protein from Crithidia fasciculata. Molecular and Biochemical Parasitology 59, 191-200. [PubMed]

Nadeau, K., Sullivan, M.A., Bradley, M., Engman, D.M. and Walsh, C.T. (1992) 83-kilodalton heat shock proteins of trypanosomes are potent peptide-stimulated ATPases. Protein Science 1, 970-979. [PubMed]

Engman, D.M., Fehr, S.C. and Donelson, J. E. (1992) Specific functional domains of mitochondrial hsp70s suggested by sequence comparison of the trypanosome and yeast proteins. Molecular and Biochemical Parasitology 51, 153-155. [PubMed]

Henkle, K.J., Cook, G.A., Foster, L.A., Engman, D.M., Bobek, L.A., Cain, G.D. and Donelson, J. E. (1990) The gene family encoding eggshell proteins of Schistosoma japonicum. Molecular and Biochemical Parasitology 42, 69-82. [PubMed]

Engman, D.M., Dragon, E.A. and Donelson, J.E. (1990) Human humoral immunity to hsp70 during Trypanosoma cruzi infection. Journal of Immunology 144, 3987-3991. [PubMed]

Engman, D.M., Sias, S.R., Gabe, J.D., Donelson, J.E. and Dragon, E.A. (1989) Comparison of HSP70 genes from two strains of Trypanosoma cruzi. Molecular and Biochemical Parasitology 37, 285-287. [PubMed]

Engman, D.M., Kirchhoff, L.V. and Donelson, J.E. (1989) Molecular cloning of mtp70, a mitochondrial member of the hsp70 family. Molecular and Cellular Biology 9, 5163-5168. [PubMed]

Engman, D.M., Krause, K.H., Blumin, J.H., Kim, K.S., Kirchhoff, L.V. and Donelson, J.E. (1989) A novel flagellar Ca2+-binding protein in trypanosomes. Journal of Biological Chemistry 264, 18627-18631. [PubMed]

Kirchhoff, L.V., Kim, K.S., Engman, D.M. and Donelson, J.E. (1988) Ubiquitin genes in trypanosomatidae. Journal of Biological Chemistry 263, 12698-12704. [PubMed]

Engman, D.M., Reddy, L.V., Donelson, J.E. and Kirchhoff, L.V. (1987) Trypanosoma cruzi exhibits inter- and intra-strain heterogeneity in molecular karyotype and chromosomal gene location. Molecular and Biochemical Parasitology 22, 115-123. [PubMed]

Walder, J. A., Eder, P. S., Engman, D.M., Brentano, S.T., Walder, R.Y., Knutzon, D. S., Dorfman, D.M. and Donelson, J.E. (1986) The 35-nucleotide spliced leader sequence is common to all trypanosome messenger RNA's. Science 233, 569-571. [PubMed]


Theses

Fridberg, A. (2008) Trypanosoma brucei Serine Palmitoyltransferase: Roles In De Novo Sphingolipid Biosynthesis, Life Cycle, and Lipid Raft Formation. Integrated Graduate Program in the Life Sciences (Evanston: Northwestern University), pp. 197.

Buchanan, K. (2005) Molecular and Biochemical Characterization of the Trypanosoma cruzi Calcium Sensor Protein FCaBP. Integrated Graduate Program in the Life Sciences (Evanston: Northwestern University), pp. 195.

Leon, J. M. (1997) A Novel Mechanism for Flagellar Protein Localization. In Immunology and Microbial Pathogenesis (Evanston: Northwestern University), pp. 180.

Godsel, L. M. (1997) A Novel Mechanism for Flagellar Protein Localization. In Immunology and Microbial Pathogenesis (Evanston: Northwestern University), pp. 180.

Medina, R. A. M. (1996) Clonagem, Caracterizacao Bioquimica e Aspectos Evolutivos da Proteina Ligante de Calcio do Flagelo (FCaBP) de Trypanosoma cruzi. In Biophysics (Rio De Janeiro: Universidade Federal do Rio de Janeiro), pp. 114.

Mello, G.K.D. (1997) Identificacao de Antigenos Recombinantes de Trypanosoma cruzi com Potencial para Diagnostico da Infeccao Chagasica Humana e sua Caracterizacao na Resposta Humoral e Celular. In Biochemistry and Immunology (Belo Horizonte: Universidade Federal de Minas Gerais), pp. 160.

Sullivan, M. A. (1993) Molecular Cloning and Characterization of a 60 KiloDalton Heat Shock Protein. In Microbiology-Immunology (Evanston: Northwestern University), pp. 178.

Tibbetts, R. S. (1995) Molecular Studies of Trypanosome Chaperone Proteins. In Microbiology-Immunology (Evanston: Northwestern University), pp. 202.